Cruises By Owner - Vacation Rentals in Eastern Panama

Play to Live San Blas in El Porvenir From US $560
         

10.0 (8 Reviews)
Boat Rental
  • TV
  • View
  • Ocean View
Cocoloco - Catamaran Lagoon 52F SAN BLAS in Narganá From US $2,158
         

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New
Boat Rental
  • Air Conditioner
  • Pool
  • Designated Smoking Area
SHAULA 5 STARS LUXURY CHARTER SAN BLAS in San Blas islands From US $1,257
         

New
Boat Rental
  • Air Conditioner
  • Designated Smoking Area
  • Bedding/Linens
San Blas- Private Yacht-All Inclusive in Cartí Sugtupu From US $444
         

10.0 (1 Review)
Boat Rental
  • Designated Smoking Area
  • View
  • Ocean View
CATAMARAN LAGOON 52 FLY LUXURY 5 STARS IN SAN BLAS ALL INCLUSIVE in San Blas islands From US $2,606
         

New
Boat Rental
  • Air Conditioner
  • Designated Smoking Area
  • Bedding/Linens
Catamaran to visit sanblas in Guna Yala Comarca From US $2,142
         

New
Boat Rental
  • Pet Friendly
  • Security/Safety
  • Bedding/Linens

Luxury Places to Stay in Eastern Panama

Over 182+ Luxury Places to Stay in or Near Eastern Panama
Catamaran experience in paradise in Guna Yala Comarca From US $915
         

New
Boat Rental
  • Designated Smoking Area
  • Child Friendly
San Blas Kids Friendly Private Catamaran. All inc+WiFi+playground. in Guna Yala Comarca From US $823
         

New
Boat Rental
  • Designated Smoking Area
  • Bedding/Linens
  • Wellness Facilities
73ft Family Sailing Yacht with Crew - all inclusive in Waisalatupo From US $750
         

10.0 (3 Reviews)
Boat Rental
  • Air Conditioner
  • View
  • Ocean View

Top-Rated Vacation Rentals with a Pool in Eastern Panama

Over 28+ Top-Rated Vacation Rentals with a Pool in or Near Eastern Panama
Ordovician Beach Resort in Isla Grande From US $459
         

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10.0 (10 Reviews)
Resort
  • Air Conditioner
  • Parking
  • Pool
Private Bedroom on Paradise San Blas Island in Narganá From US $183
         

10.0 (1 Review)
House
  • Pool
  • Balcony/Terrace
  • Security/Safety
Ordovician Beach Resort in Isla Grande From US $462
         

9.9 (10 Reviews)
Resort
  • Air Conditioner
  • Parking
  • Pool
Ranchos de Chalia in Puerto Lindo From US $137
         

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9.8 (18 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool
Ciel y Miel in Cacique From US $228
         

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9.8 (12 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool
Cabañas Blue in Isla Grande From US $94
         

9.1 (136 Reviews)
Hotel
  • Air Conditioner
  • Pet Friendly
  • Pool
Hotel Candy Rose in Colón From US $189
         

9.0 (352 Reviews)
Hotel
  • Air Conditioner
  • Pool
  • View
Ranchos de Chalia Panama in Portobelo From US $161
         

8.9 (109 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pet Friendly

Pet-Friendly Vacation Rentals in Eastern Panama

Over 27+ Pet-Friendly Vacation Rentals in or Near Eastern Panama
Caribbean getaway: beach cottage just on the sand in Palenque From US $359
         

9.0 (4 Reviews)
Cottage
  • Air Conditioner
  • Parking
  • Pet Friendly
Macondo Hostel in Isla Grande From US $45
         

9.1 (228 Reviews)
Hostel
  • Air Conditioner
  • Pet Friendly
  • Designated Smoking Area
Despierta sobre el mar in Garrote From US $108
         

6.0 (1 Review)
House
  • Air Conditioner
  • Parking
  • Pet Friendly
BouMou Sailboat in Guna Yala Comarca From US $341
         

New
Boat Rental
  • Pet Friendly
  • Designated Smoking Area
  • Balcony/Terrace
Bayview Puerto Lindo in Garrote From US $99
         

New
Condo
  • Air Conditioner
  • Parking
  • Pet Friendly
Breakfast, lunch, dinner, excursions, snorkeling and fishing equipment inclusive in San Blas From US $180
         

Deluxe Beachfront 4-bedroom house in Colón Province in Colón Province From US $305
         

New
House
  • Air Conditioner
  • Pet Friendly
  • Security/Safety
Beautiful beach front house in the Caribbean in Palenque From US $240
         

New
House
  • Air Conditioner
  • Pet Friendly
  • Designated Smoking Area

Large Vacation Homes & Villas in Eastern Panama

Over 42+ Large Vacation Homes & Villas in or Near Eastern Panama
Casa Frente al Mar - Isla Grande in Provincia de Colón From US $400
         

10.0 (1 Review)
House
  • Designated Smoking Area
  • Entertainment
  • Child Friendly
Islas de San Blas habitacion en Narasgandub in Mamartupo From US $117
         

10.0 (3 Reviews)
Apartment
  • Security/Safety
  • Bar
  • Child Friendly
San Blas Tour Aridub in Narganá From US $144
         

Private cabin in San Blas in Carti Tupile From US $289
         

Icodub island, San Blas cabins in Panama From US $469
         

New
Cabin
  • Designated Smoking Area
  • TV
  • Child Friendly
Island Hopping on Luxury Private Crewed All-Inclusive Yacht in Río Azúcar From US $2,727
         

New
Boat Rental
  • Air Conditioner
  • Security/Safety
  • Bedding/Linens

Wheelchair Accessible Vacation Homes in Eastern Panama

Over 1+ Wheelchair Accessible Vacation Homes in or Near Eastern Panama
Basi Resort in Nombre de Dios From US $83
         

8.4 (5 Reviews)
Hotel
  • Air Conditioner
  • Parking
  • Pool

Eastern Panama Vacation Rentals and Airbnb Places to Stay Under $200

Over 73+ Eastern Panama Vacation Rentals and Airbnb Places to Stay Under $200
Private Room in San Blas Islands PLUS meals in Waisalatupo From US $172
         

8.6 (27 Reviews)
Cabin
  • View
  • Private Beach
  • Ocean View
Discovery Gunayar in Narganá From US $134
         

6.0 (1 Review)
Cabin
  • Security/Safety
  • Bedding/Linens
  • Guest Services
Disfruta una noche en las islas de San blas Guanidub in Mamartupo From US $185
         

san blas luxury tour in Nusatupo From US $152
         

New
Cabin
  • Designated Smoking Area
  • View
  • Ocean View
- SV La Francesca - san blas paradise on bord of private sailboat in Carti Tupile From US $138
         

Islas de San blas cabaña privada en Tubasenika in Mamartupo From US $135
         

Instantly Bookable Vacation Homes in Eastern Panama

Over 8+ Instantly Bookable Vacation Homes in or Near Eastern Panama
Exclusive sailboat for 2 people all inclusive in San Blas islands in Guna Yala From US $530
         

10.0 (1 Review)
Boat Rental
  • Designated Smoking Area
  • View
  • Ocean View

About Eastern Panama Vacation Rentals

With more than 53 Eastern Panama vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Cruisesbyowner and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at a rental property in Eastern Panama.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With Cruisesbyowner Eastern Panama, you have the flexibility of comparing different options of various deals with a single click. Looking for a rental by owner with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner, and other popular Airbnb-style properties in Eastern Panama. Places to stay near Eastern Panama are 115.25 ft² on average, with prices averaging US $1,055 a night.

Cruisesbyowner makes it easy and safe to find and compare vacation rentals in Eastern Panama with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Top Rental Accommodation Types in Eastern Panama

Type Count

Use these Quick Filters to Find a Vacation Rental in Eastern Panama

Pro Tip: Cruisesbyowner makes it easy to compare the best listings on Cruisesbyowner homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between Cruisesbyowner homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in Eastern Panama.

Weather in Eastern Panama

View the weather forecast for Eastern Panama before booking your Eastern Panama Vacation Rentals to confirm your best time to go.

December - February
High 91°F       Low 70°F
March - May
High 92°F       Low 71°F
June - August
High 91°F       Low 72°F
September - November
High 87°F       Low 73°F

Eastern Panama Vacation Rental Frequently Asked Questions

What are the top vacation rentals in Eastern Panama?
How many vacation rentals are available in Eastern Panama?

Currently, the total number of properties listed in 2026 is over 53 in the Eastern Panama area, and still counting. By aggregating listings from multiple websites, offers an immense amount of choice of the best properties in Eastern Panama.